Arthritis Research & Therapy - Latest articlesThe latest articles from Arthritis Research & Therapy (ISSN 1478-6354) published by BioMed CentralNovel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis- July 1, 2008 IntroductionDespite the advent of biological therapies for treatment of rheumatoid arthritis (RA), there is a compelling need to develop alternative therapeutic targets for non-responders to existing treatments. Soluble receptors occur naturally in vivo, such as the splice variant of the cell surface receptor for vascular endothelial growth factor (VEGF), a key regulator of angiogenesis in RA. Bioinformatics analyses predict that the majority of human genes undergo alternative splicing,...http://arthritis-research.com/content/10/4/R73 |