Virology Journal - Latest articlesThe latest articles from Virology Journal (ISSN 1743-422X) published by BioMed CentralIn vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity- May 31, 2008 Background: Selenium (Se) deficiency plays an important role in viral pathogenesis. To understand the effects of Se deficiency on West Nile virus (WNV) infection, we analyzed cytopathogenicity, apoptosis and viral replication kinetics, using a newly developed Se-deficient cell culture system. Results: Both Vero and SK-N-SH cells grown in Se-deficient media exhibited a gradual loss of glutathione peroxidase (GPx1) activity without any significant effect on cell growth and viability. In...http://www.virologyj.com/content/5/1/66 |