The NewiBlogNews and comments on protein biochemistry, protein crystallization, and drug discovery.(Untitled)- October 23, 2002 PNAS: Structure of HIV-2 reverse transcriptase at 2.35-Å resolution and the mechanism of resistance to non-nucleoside inhibitors. This structure from Ren et al. suggests a mechanism behind the inherent resistance of the HIV-2 RT to NNRTIs and should help in the development of a new class of NNRTIs that are effective against HIV-2.http://radio.weblogs.com/0103798/2002/10/23.html#a19 (Untitled)- October 23, 2002 Nature Structural Biology: Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Lim and Strynadka reveal structural features that confer methicillin resistance and are responsible low affinity beta-lactam antibiotic binding by the high molecular weight penicillin binding protein PBP2a.http://radio.weblogs.com/0103798/2002/10/22.html#a18 (Untitled)- October 12, 2002 Bacterial multidrug export: Structure of E. coli protein AcrB. Crystal structure of bacterial multidrug efflux transporter AcrB. SATOSHI MURAKAMI , RYOSUKE NAKASHIMA, EIKI YAMASHITA & AKIHITO YAMAGUCHI Nature 419, 587-593 (2002).http://radio.weblogs.com/0103798/2002/10/11.html#a17 |