The Journal of Cell Biology current issueThe Journal of Cell Biology RSS feed -- current issuePlectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape- June 16, 2008 Plectin is a versatile intermediate filament (IF)–bound cytolinker protein with a variety of differentially spliced isoforms accounting for its multiple functions. One particular isoform, plectin 1b (P1b), remains associated with mitochondria after biochemical fractionation of fibroblasts and cells expressing exogenous P1b. Here, we determined that P1b is inserted into the outer mitochondrial membrane with the exon 1b–encoded N-terminal sequence serving as a mitochondrial targeting..http://www.jcb.org/cgi/content/short/181/6/903?rss=1 A better way to see splicing partners- June 16, 2008http://www.jcb.org/cgi/content/short/181/6/875-a?rss=1 p190RhoGAP is the convergence point of adhesion signals from alpha5beta1 integrin and syndecan-4- June 16, 2008 The fibronectin receptors 5β1 integrin and syndecan-4 cocluster in focal adhesions and coordinate cell migration by making individual contributions to the suppression of RhoA activity during matrix engagement. p190Rho–guanosine triphosphatase–activating protein (GAP) is known to inhibit RhoA during the early stages of cell spreading in an Src-dependent manner. This paper dissects the mechanisms of p190RhoGAP regulation and distinguishes the contributions of 5β1 integrin...http://www.jcb.org/cgi/content/short/181/6/1013?rss=1 NGF Inhibits MKCNQ Currents and Selectively Alters Neuronal Excitability in Subsets of Sympathetic Neurons Depending on their MKCNQ Current Background- June 16, 2008http://www.jcb.org/cgi/content/short/181/6/i21?rss=1 Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis- June 16, 2008http://www.jcb.org/cgi/content/short/181/6/i20?rss=1 MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity- June 16, 2008http://www.jcb.org/cgi/content/short/181/6/i22?rss=1 The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA- June 16, 2008 Invadopodia are actin-based membrane protrusions formed at contact sites between invasive tumor cells and the extracellular matrix with matrix proteolytic activity. Actin regulatory proteins participate in invadopodia formation, whereas matrix degradation requires metalloproteinases (MMPs) targeted to invadopodia. In this study, we show that the vesicle-tethering exocyst complex is required for matrix proteolysis and invasion of breast carcinoma cells. We demonstrate that the exocyst subunits...http://www.jcb.org/cgi/content/short/181/6/985?rss=1 Complementary receptors control RhoA- June 16, 2008http://www.jcb.org/cgi/content/short/181/6/874?rss=1 Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase- June 16, 2008 The SCFFBW7 ubiquitin ligase degrades proteins involved in cell division, growth, and differentiation and is commonly mutated in cancers. The Fbw7 locus encodes three protein isoforms that occupy distinct subcellular localizations, suggesting that each has unique functions. We used gene targeting to create isoform-specific Fbw7-null mutations in human cells and found that the nucleoplasmic Fbw7 isoform accounts for almost all Fbw7 activity toward cyclin E, c-Myc, and sterol regulatory element...http://www.jcb.org/cgi/content/short/181/6/913?rss=1 Centromeres cross over, a lot- June 16, 2008http://www.jcb.org/cgi/content/short/181/6/874-a?rss=1 |